belstaff italia Effects of selenium on rat embryon

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Effects of selenium on rat embryonic spinal cord neurons in vitro proliferation and differentiation

996.14 (1) :20-21 [2] Qiao Jianjun, Lian-Xiang Du. Bacillus subtilis glucose dehydrogenase gene cloning and sequence analysis [J]. Industrial Microbiology. 2001,31 (3) :23-28. [3] Jinfang, nationality Xiaotao, Lian-Xiang Du D-glucose dehydrogenase method of determination - Bacillus pumilus in 【) - ribose Production [J]. Tianjin Institute of Light Industry. 2001.3 (1) :37-40 [4] BaikSH,[link widoczny dla zalogowanych], IdeT,[link widoczny dla zalogowanych], YoshidaH. etalSignificantlyen-hancedstabilityofglucosedehydrogenasebydirectedevo-lution [J]. ApplMicrobiolBiotechno1.2003.61 (4) :329-335. [Received】 2003-05-21 (Continued from page 6) 3, Se, although the discussion is essential trace element for organisms, but concentrations exceeding the safety threshold, it will produce toxic effects on the body's cells. The study found high concentrations of Na, SeO (50.0 ~ 200.0gmol / L) reduced neuronal survival rate and colony formation rate, the cytotoxic dose-effect relationship. Now that the toxicity of selenium compounds may be related to the ability to generate reactive oxygen species related. In vitro studies found that selenite restore glutathione reaction with reactive oxygen species. Further research showed that when hydrogen peroxide (H, O.) there is, the reaction of selenite with GSH produced a sharp increase in reactive oxygen species. GSH content in cells so rich, H, o, a high level of condition, when the selenium concentration in the culture medium up to a certain extent,[link widoczny dla zalogowanych], the generation of reactive oxygen species will lead to oxidative damage to cells, including proteins (enzymes) membrane damage and cause lipid peroxidation, eventually leading to neuronal apoptosis. Cells with high concentrations of toxic effects caused by contrast, low concentrations of selenium (1.0 ~ 10.0gmol / L) on the embryonic spinal cord nerve cell survival, growth, differentiation and protein synthesis a facilitating role. This may be the expression of selenium to promote nerve cell NGF, IGF and other neurotrophic factor and c-los, c-ion and other related transcription factors. These results suggest NaSeO. On cell proliferation and differentiation has dual effects of selenium on the biological role of embryonic neural cell properties and dose-related. So. Preparations on the human body should control the use of selenium in selenium concentration. Especially for pregnant women can not be blindly applied selenium preparations in order to avoid fetal nervous system abnormalities. The biological mechanism of action of selenium and its relationship with the dose to be further studied from the molecular level. In this study the cellular level provides the safe use of selenium in vitro data. [
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