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Adverse Tabk4AdversereactionofMS. Contin side effects number of cases (%),[link widoczny dla zalogowanych], constipation, dizziness, nausea, vomiting, difficulty in expectoration difficult urination drowsiness 3 discussed in China, according to a report in 1997, 27 provinces (autonomous regions) in a sample survey of 19,901,992, accounting for malignant liver cancer mortality No. 2 cancer mortality in men secondary to gastric cancer, gastric cancer and esophageal cancer in women secondary to account for the first three. ... Therefore, how to reduce pain in patients with advanced liver cancer in front of us is urgent need to address the important issue. Recommended by the World Health Organization on behalf of moderate to severe pain control drugs are morphine, one of the important principles of pain treatment is individualized dosing J. Analgesic formulations can only maintain normal 23h, MS Contin is a long-acting controlled release dosage forms, will extend morphine 8-12h, three morphine formulations of existing (ie, immediate-release morphine sulfate tablets J, morphine sulfate morphine sulfate sustained-release tablets and controlled-release tablets I4】) the best drug. [1】 Lian-section, Zhang Siwei, Lufeng Zhu, et al. And classification of cancer death in China constitute the characteristics of spectrum. Chinese Journal of Cancer, 1997,19:323. [2】 WorldHealthOrganization. Cancerpainrelief. WorldHealthOrganization, Geneva, 1986. 【3】 ThirlwellMRSloanPA, MarounJA, eta1. Pharmacokineticsandclinicalefficacyoforalmorphinesolutionandcontrolled-releasemorphinetabletsincancerpatients. Cancer, 1989,63:2275. [4】 BloomfieldSS, CissellGB, MitchellJ,[link widoczny dla zalogowanych], eta1. Analgesicefficacyandpotencyoftwooralcontrolled-releasesmorphinepreparation. ClinPharmacolTher, 1993,53:469 [5】 TsunetoS, HayashiA, MiyzakiM, eta1. Aclinicalsurveyofcontrolled-releasemorphinesulfateforcancerpainreliefinaJapanesehospice. PostgradMedJ, 199l, 67 (suppl2) :79-81. [6】 KimBs, ChungHC. Experiencewithacontrolled-releaseoralmorphineforcancerpmnmanagement. PostgradMedJ, 1991,67 (suppl2): 86. [7】 RobertRobertETheUnitedStatesexperiencewithoralcontrolled-releasemorphine. Cancer ,[link widoczny dla zalogowanych],1989,63:2346-2354. [8】 PortenoyRK, MaldonaldoM, FitzamartinR, eta1. Oralcontrolled-releasemorphinesulfate; Analgesicefficacyandsideeffectsof100mgtabletincancerpainpatients. Cancer, 1989,63:2284. [9】 Luo G, has apricot Health, million will be flat, and so on. MS Contin tablets in the treatment of advanced cancer pain. Chinese Journal of Clinical Oncology, 2000,27 (2): 141. [101MaloneyCM,[link widoczny dla zalogowanych], KesnerRK, KleinG, eta1. TherectaladministrationofMScontin: clinicalimplicationofuseinendstagecaccer. AmJhospiceCare, 1989.6:34. ∽ 242l33l
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