uggs kopen Selenomethionine on the role of human c

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Selenomethionine on the role of human colon cancer

Different selenium as a cancer chemopreventive agent. Different chemical forms of selenium levels of different cancer may be related to their metabolism in the body cells. Assume that the methyl Se selenomethionine into alcohol,[link widoczny dla zalogowanych], for its anti-cancer effect has an important role. In animals, kidney and liver are the main organs of selenium metabolism by methylation of selenomethionine to selenium in the middle of one at least 5 steps. Colon and prostate epithelial cells have a low selenium methionine metabolism in the methylation of selenium as a single capacity. Many studies have tried to apply inorganic selenium to organic selenium anti-cancer effect, or the concentration of selenomethionine increased to physiological levels of 20 - 100 times to achieve the anti-cancer effects. However,[link widoczny dla zalogowanych], in vivo studies of high concentrations of selenium methionine, selenomethionine may not reflect the physiological concentration in human anti-cancer effect. 4 anti-cancer effect of selenium methionine Goulet molecular biology research such as selenium methionine can lead to evidence of cell growth arrest, cell growth inhibition and S-G / m cell cycle arrest related. In addition to cell cycle arrest, the cell cycle 165 protein B and cyclin-dependent enzymes increase the phosphorylation of Cdc2. Because the factors of a cascade of activated protein kinase activity in the maintenance and cell cycle arrest and growth retardation associated researchers evaluate whether MAP kinase can be activated selenomethionine. In this study, did not see activation of JNK or p38, but found that selenomethionine resulted in enzyme extracellular signal regulated (ERK) in the appropriate physiological concentrations (such as 22j on the tn0l selenomethionine), the dose-dependent phosphorylation. It also shows that selenomethionine resulted in ribosome S6 kinase (p90RSK) phosphorylation. In addition, the discovery of histone H3 on serine dose-dependent phosphorylation. In addition, p90RSK and histone H3 phosphorylation by MEK inhibitor U0126 antagonized means selenomethionine caused p90ESK and histone H3 phosphorylation, at least in part dependent on the ERK pathway. Conclusions based on those proposed selenomethionine led to growth arrest and histone H3 phosphorylation, is the activity of ERK and p90ESK to regulation. These data provide clinically appropriate selenomethionine concentration in the biological effects of the valuable point of view. There is no doubt, other important mechanisms, such as gene promoter methylation in polyunsaturated fatty acid metabolism and DNA repair in response to changes in the adjustment process may also be anti-cancer effect of selenium methionine play a role . Future research should directly examine the mechanism of growth retardation in the body will occur. 5 Conclusions At present,[link widoczny dla zalogowanych], there is no evidence yet of any other dietary selenium compounds have more nutrients than the cancer prevention potential. Clinical studies of COX-2 inhibitor review, stressed the need to identify an effective, non-toxic chemopreventive agent. Although there is a gap, but the anti-cancer effect of selenium on the molecular basis of biology and biochemistry, as well as epidemiological evidence and preclinical studies have shown that selenium compounds as a potential colon cancer chemopreventive agent, has been very clear. For selenium and selenium in the complexes with other compounds in clinical trials,[link widoczny dla zalogowanych], and preclinical studies may be new therapeutic strategy for colon cancer generation.
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