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Probiotics in rat model of mild hepatic encephalopathy and mechanism of the experimental treatment

5). Chinese Journal of Digestion September 2004 Volume 24 No. 9 ChinJDig, Sep. 2004,[link widoczny dla zalogowanych], vol24, No. 9 Table 1 probiotics on the incidence of MHE, serum endotoxin, ammonia and liver function indexes --- 553 --- probiotics in Table 2 Histology of rat liver Improvement of discuss the latest areas of consensus that HE is a continuous phase, including from the MHE (0 period) to HE (Ⅳ period) and other types of varying degrees. Study found that patients with cirrhosis of intestinal flora, Bifidobacterium, Bacteroides and Eubacterium significantly reduced, while the number of potential pathogens (eg Clostridium perfringens, E. coli, etc.) increased significantly with the intestinal endotoxemia,[link widoczny dla zalogowanych], HE morbidity and multiple organ failure are closely related l4J. Oral administration of Lactobacillus and Bifidobacterium and more joint preparation can not only correct the imbalance of intestinal flora, inhibit bacterial spoilage and the growth of urease, and to acidification of intestinal tract, reduce ammonia and endotoxin levels, reduce liver cirrhosis cell injury and cell organelles deformation, slow down the formation of false lobules,[link widoczny dla zalogowanych], improve liver function and reduce symptoms, higher ratio of Bifidobacteria and E. coli, complications of cirrhosis (such as HE, spontaneous bacterial peritonitis) have a preventive effect [. In this paper, the establishment of small doses of TAA in rats based on the MHE model to include Bifidobacterium longum, Streptococcus thermophilus and Lactobacillus three beneficial bacteria probiotics preparations for the representatives of probiotics on the MHE were The experimental treatment study, found that exogenous Bifidobacterium and Lactobacillus,[link widoczny dla zalogowanych], not only can effectively reduce the high ammonia and high endotoxemia, but also to improve liver function and liver pathology, the occurrence rate of 83.3% MHE fell to 33.3%, indicating MHE model of TAA caused significant prevention effect, inference and probiotics in Bifidobacterium, Streptococcus thermophilus and Lactobacillus have three enteric bacteria by regulating the colon flora, intestinal acidification, reduce ammonia and other intestinal endotoxin and other factors related 【endotoxemia. In view of microbial therapy is safe and effective, no obvious side effects, and good clinical compliance, is expected to become the ideal alternative to lactulose,[link widoczny dla zalogowanych], especially for patients with lactulose HE invalid. As for the probiotics and lactulose MHE prospective randomized controlled clinical studies are under way.
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