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Glutathione transferase enzymes of population polymorphism and susceptibility to chronic benzene poisoning Meta-Analysis

. 482155306316.9O2342264713.750.980.42-2.262433225313.915592459821.7O1.750.98-3.11 eleven thousand one hundred and eleven 213314286.821.750.63-4.8863110378019.36821617113746.620.960.61- 1.52721357114921.15 1111111 2741317416. O1 eleven thousand one hundred and eleven values of the value of ~ a 253793112.68208290171365100.001.310.98-1.75232411200450100.00 9sg0.681.33 ~ 1.423.761.47-9.631.56O. 87 ~ 2.781.260.79 ~ 2. O02.681.21 ~ 5.925. O91.81 ~ 14.361.851.1O ~ 3.12GSTT1 each other with the GSTM1 isozyme. GSTs have catalytic glutathione (GSH) with a variety of pro-electronic substrate binding function, thereby eliminating electrophilic compounds and exogenous oxidative stress caused by the harmful effects. Because GSTM1 and GSTT1 null genotype may lead to lack of enzyme function, allowing a lack of detoxification activity of pro-E genotype in the middle of a reduced ability of metabolites,[link widoczny dla zalogowanych], GSTM1 or GSTT1 gene deletion may lead to increased susceptibility to chronic benzene poisoning. However, recent studies found that GSH and GST are also able to catalyze the toxic benzene metabolites benzoquinone and glutathione in the bone marrow to form hydroquinone (GHQ), the GHQ with hematologic toxicity, the occurrence of GSTs in benzene poisoning played in role remains to be elucidated. GST gene polymorphism and susceptibility to chronic benzene poisoning in workers also smoking, drinking, and other genetic polymorphism (NQO1,[link widoczny dla zalogowanych], CYP2E2, etc.) there is interaction. Because of these factors, the data collected in this there are different conclusions, even the same authors in different studies come to different conclusions 3]. Therefore,[link widoczny dla zalogowanych], it is necessary for a comprehensive analysis of these data. Meta analysis is a result of the merger of several similar aggregate analysis,[link widoczny dla zalogowanych], the research data on the different conclusions can be obtained by Meta analysis closer to a comprehensive analysis of the real situation. Gene polymorphism and susceptibility to chronic benzene poisoning Meta-analysis literature, GSTT1 gene polymorphisms with susceptibility to chronic benzene poisoning was not statistically significant (combined 0R a 1.31,[link widoczny dla zalogowanych], P> 0.05) as P value is very close to 0.05, sample size may be less, and therefore our population being speculated that GSTT1 gene polymorphism and susceptibility to chronic benzene poisoning no obvious relationship in the future need for further studies. GSTM1 gene polymorphism and susceptibility to chronic benzene poisoning combined OR = 1.85, a statistically significant (P <0.05), shows that our population of GSTM1 gene polymorphism and susceptibility to chronic benzene poisoning a certain relationship. Tips for the GSTM1 gene deletion of the people should avoid exposure to benzene in the operation. Because of this standard are the literature collected only seven, and concentrated in flavor and Chen Yan Chun million research group led by a research report of the study sample size less than normal, coupled with the existence of ethnic diversity in China. Accordingly, GST gene polymorphisms and susceptibility to chronic benzene poisoning, especially GSTT1 gene polymorphisms with susceptibility to chronic benzene poisoning needs further study.
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