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Note: DM group PLT slightly lower than the control group ( P <0.05), while the MPV, PDW, and no significant increase in GHb, the difference with the control group was significant (P <0.01)
Platelet parameters and glycosylated hemoglobin in diabetic patients with combined detection of the significance of microvascular lesions

[Abstract] Objective To observe the platelet parameters and glycosylated hemoglobin in diabetic patients with combined detection of the significance of microvascular lesions. Methods 40 cases of ABX blood cell analyzer diabetes (DM) patients and 40 healthy adults PLT, MPV,[link widoczny dla zalogowanych], PDW and Immunoturbidimetry GHb joint inspection. The results showed that differences between DM and control groups was significant. PLT (155.7 ± 50.3) × 109 / L (P <0.05), MPV (12.5 ± 2.45) fl (P <0.01), PDW (16.31 ± 1.25) fl (P <0.01), GHb (9.65 ± 1.29)% ( P <0> 3.0g / L (+), excluding urinary tract infection; (3) symmetry of sensory dysfunction clinically, but the exclusion of other -induced neuromuscular diseases.

2 results
1.2.1 Determination of platelet parameters in the subjects taken at the special blood tubes 0.5ml venous blood, the use of ABX reagents, according to ABX -60 measured blood analyzer routine procedure PLT, MPV, PDW.
PLT mainly from bone marrow megakaryocytes mature, a few (1% ~ 17%) from pulmonary megakaryocytes, platelet number and volume of circulating platelets reflect the age, size large platelets are young platelets, the cells mass density is low, metabolic activity [1]. Generally believed that, because the body's immune function, aging and more destructive small platelet, small thrombocytopenia, a young doctor, the relative increase in the platelet, MPV increased. In addition, patients with bone marrow damage caused by PLT BM decreased significantly, while the MPV, PDW increased significantly, the results easily lead to the occurrence of microvascular disease.

1.2 Methods
1.1 General Information
Table 1 DM patients and normal control group, PLT Comparison of measured parameters and GHb (omitted)
GHb levels were negatively related to DM control, control, worse, GHb level is higher, the literature describes GHb> 9.0%, the prediction accuracy of about DM 78%,[link widoczny dla zalogowanych], sensitivity 68%, specificity of 94%. In the cases we observed, DM patients with retinal GHb at about 8.36% ~ 10.94%, indicating mild to moderate lesions, laser treatment is available. GHb> 11.0%, generally considered a serious lesion, the prognosis is poor. So that, PLT, MPV, PDW and GHb complementary role of combined detection of targets, both early detection of the presence of microvascular disease, but also suggest the degree lesions, in monitoring the incidence of DM patients with microangiopathy and prognosis has important significance.

DM patients with microvascular disease and micro-capillary basement membrane thickening is characterized by thrombosis, including retinopathy, nephropathy and neuropathy. DM function in peripheral blood of young relative increase in platelet activity, platelet aggregation induced hypercoagulable state, therefore, DM patients with retinopathy and kidney disease process, changes in platelet parameters of great importance.

1.1.1 control group of 40 normal subjects by qualified medical cases, including 25 males and 15 females, age range 24 to 50 years old.

DM patients and normal control group GHb determination of PLT parameters and results are compared in Table 1. More articles related to topics：

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