Oakley Sunglasses Colorectal cancer patients and c

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Colorectal cancer patients and cancer of the bile acid content

Without lymph node metastasis in 16 patients. Review the original medical records of 26 cases of liver function tests in the record: zinc sulfate turbidity, all of a aminotransferase,[link widoczny dla zalogowanych], y one of the GT,[link widoczny dla zalogowanych], alkaline phosphatase were normal, Hb-sAg, AFP were negative. 3o cases of normal human serum bile acid concentration in the range o. 86 ~ 4.9, with more than 5.2, an average of 1995, Volume 22 of Clinical Oncology 5, 2.60 ± 0.24,[link widoczny dla zalogowanych], compared two groups of serum bile acid concentration was a significant difference (dead < O.001), see table. Schedule of serum bile acid content in colorectal cancer rates compared with the normal (unit: nmol/m1) colon cancer patients with preoperative serum bile acid levels in patients with age, sex, tumor site occurred, tumor differentiation and lymph node metastasis analysis, no significant difference. 3 Discussion epidemiology, animal experimental study [and fecal bile acid content in cancer patients studies confirmed the high concentration of bile acids in the intestine leading to colorectal cancer is one of the important reasons. In colorectal cancer were found to have a special acid receptor protein exists mouth], also shows that bile acids and colorectal cancer are closely related. Of the acid with the newly developed ion-selective microelectrode analysis further confirmed the acid content in colorectal cancer mucosa cells 3.84-fold higher than normal, the difference was statistically significant (dead <O.001), illustrate the level of bile acids from the living cells in colorectal cancer are closely related. Mechanism for the occurrence of colorectal cancer provides a valuable basis for the interpretation of cellular level. Acid tumor promotion mechanism may be multifaceted. Acid itself is a highly biologically active substances. Its structure is similar to the carcinogenic polycyclic aromatic hydrocarbons. Anaerobic acid can break down the large intestine into methylcholanthrene, cyclopentane Philippines and other carcinogenic substances. Cheah study found that first-class people can directly influence the DNA bile acid metabolism, M single-helix structure of phage DNA transcription efficiency of the attenuation of bile acid 1,000 times. Acid can change the permeability of cell membranes of certain substances, promote the absorption of carcinogens, bile acids can change the morphology and kinetics of intestinal cells and promote proliferation of colon cells, thereby contributing to damage caused by carcinogens Expression of r. Detection of colorectal cancer with PEG within the acid content of cell lysate, cell lysate of normal intestinal bile acid content in 3.99 times, and living micro-electrodes measured acid content in colon cancer cells is normal intestinal cells is very close to 3.84 times. 5O patients with colorectal cancer detected in the patients with preoperative serum bile acid concentration, simultaneous detection of serum bile acid levels 3O normal subjects to compare the two groups was a significant difference (dead <0.001). 52 patients with colorectal cancer (26 cases) higher than the normal range of serum bile acid, of which 16 (61.5) without lymph node metastasis; the 26 patients with various indicators of liver function tests were normal. Experimental Tip: serum bile acid levels increased, after the exclusion of hepatobiliary system diseases, to consider the possibility of suffering from colon cancer.
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