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Methotrexate in patients with primary liver albumin microspheres after hepatic artery embolization Drug Distribution

Pulp, 3000r/mln centrifuge 10min, isolated from supernatant, the supernatant determined by FPIA method guillotine walked the banks of a fluoride concentration of butterflies. The final organization of drug concentrations in nmol / g. 5. Data processing: the groups using t test between each set of data to determine if there is statistically significant. 8 down the original results of liver cancer patients Li F Butterfly Ridge albumin shake a ball after hepatic artery Lian plug some time, a fluorine Butterfly - offspring in hepatic inferior vena cava. Liver cancer tissue levels of drugs in Table 1 with open eyes wrapped in a fluorine butterfly logo ball albumin in vivo drug hepatic artery embolization in 8 patients down, 7 cases were stable,[link widoczny dla zalogowanych], is still alive and followed up for 6 October, 2 down AFP Check the negative, 6 cases of B-ultrasound lesions neoplasms have possession of the product of two small diameter,[link widoczny dla zalogowanych], the other an inverted neoplasms Although there is no narrow focus, but no new lesions. This group of patients, only one case of postoperative recovery is poor, there belly wood, hypoproteinemia, liver and kidney failure and hemorrhagic shock,[link widoczny dla zalogowanych], eight days, the National Science Foundation from the clamor died. Discussion of the effect of chemical anti-cancer drugs and places where the parts of arsenic effective blood drug concentration and the concentration levels of drugs and swollen places under the contact time were positively correlated. 8 down train set under the liver in patients with methotrexate inferior vena cava blood concentration of 5-ling attack, only a short plug in Guangxi measured 5 days after methotrexate concentration 0.08ptool / L, the remaining 4 attack concentrations were below the minimum detection limit. The liver and cancer tissue even in the way Cypriot ship day after surgery were still 0.10ntool / g,[link widoczny dla zalogowanych], o02nmol / g in the methotrexate drug content. This result is a conclusion consistent with animal experiments ... that methotrexate hepatic artery peak albumin logo ball stopper depression after the swollen ridicule both organizations to improve the local drug concentration and maintain effective when asked, but also reduce the systemic circulation thereby reducing the systemic drug concentration toxicity. In recent years, chemotherapy of primary liver cancer treatment has been widely Lian Cypriot attention of several different chemotherapy drugs microspheres after another. ... Microspheres are mostly biodegradable matrix material, the degradation period of 1 month or so, after degradation revascularization. The group _ the first 33 days after silicone plug still guillotine carcinoma of liver and methotrexate brick, that emblem of the drug in vivo biodegradation of the ball for at least more than five weeks. That the emblem of methotrexate albumin role of the ball more durable Gui plug, so shoes can be repeated to avoid short-term plug to reduce the unnecessary suffering of patients and the burden of albumin by the crowd as the microsphere matrix has cast some of the other matrix advantages, it comes from human blood after embolization and the reticuloendothelial system can not easily be swallowed mononuclear cells as heterogeneous and remove shoes.
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