mbt italia 抗MHCⅡ类&#25239

defgf10aj

,[link widoczny dla zalogowanych]
抗MHCⅡ类抗原单克隆抗体人血清蛋白氨甲喋呤结合...
manostcogenicsarco—maeells．CancerResI986，46(占)；24076NoriakiE，eta1．1nvitrocYtotoxi—cityofahumanSC1~Unlalbumin—me一·dintedconiugateofmethotrexatewi恤-anti—MM46monocloHalantibody．CancerRes1987；47(4)_107B．(收稿1989—12—26修回1990—0I一04)．CharacteristicsofaHumanSerumAlbumin—MediatedConjugateofMethotrexatewithAnti—MHCClassIIMonoclonalAntibodyHaoLet，MangWenx~e。，ShenSuyun,[link widoczny dla zalogowanych]，HuShenhui．Sm,Bfnzhong。TanWeiquanandChenZhang(DepartmentofHematology，XijingHospital,[link widoczny dla zalogowanych]，TheFourthMilitaryMedicalUniversity．Xiall710032)(DepartmentofToxicologyTheFourthMilitaryMedicalUniversity，Xil&n710032)(InstituteofHematology，ChineseAcademyofMedicalSciencesTianjing300020)AbsttactInthestudiesonantibody—drugconjugaLosaspotentiaipurgingagentsiNhonemarrowtransplantatlon．MTx，coupledwithHSAbymeansofcarbondiimide,[link widoczny dla zalogowanych]，WasconiugatedwithakindofmurinemonoclonalantibodytoMHCⅡantigenusingHSA0sanjntermediafor．州TX．HSAwasCOndjtionedtohaveabout】toolofthiolgrouppertoolofHSAbydithiothreltoltreatment．theresultingSH—HSA—MTXthenbeingreactedwithimmunoglobulinmodiliedwiththePDPgroup．Theconjugates~H148一HSA—MTx,[link widoczny dla zalogowanych]，whichinhibited80ofgrowthra№oftargetcell—Rajiand40ofgrowthrateofnontargetcell—Molt4atadoseof&tg／mlofMTx，retainedbothantibodylbindinganddrugactivities．ThecytotoxicitywalockedbyunconjugatedHi43．WhentheconjugatesreachedthedosagecapableofmaximalkillingRajicells。therewas11otoxicitytomuItipotentiaIprogenito：s(CFU—GM，innormalhumanbonemarrow．Key~"aordsantibodies，monoclonaljmethotrexate；cytot0xicity；MHCclassIIanti—genantibody—drugcoajugate
More articles related to topics：

[link widoczny dla zalogowanych]

[link widoczny dla zalogowanych]

[link widoczny dla zalogowanych]